Doctoral Researcher / PhD Candidate

Scope of duties

The Department of Dermatology and Allergology (Director: Prof. Michael Flaig) is part of the newly established Transregional Collaborative Research Center (CRC) 425 “Desmosomal Dysfunction in Epithelial Barriers” (DEFINE). The mission of this multidisciplinary research consortium is to uncover cellular mechanisms underlying desmosomal dysfunction. CRC 425 combines cutting-edge technologies and translational approaches using patient-derived samples.

Subproject B03 is led by Prof. Lauffer in Munich and Prof. Yazdi in Aachen. Together, we aim to elucidate mechanisms of desmosomal detachment in various skin diseases, with a particular focus on the interplay between pro-inflammatory cytokines, cell death, and desmosomal function. To achieve this, we will use primary human cells (keratinocytes and T cells), three-dimensional skin models, and patient-derived skin biopsies in combination with state-of-the-art imaging and omics technologies.

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