PhD student – Development of high-content-based cellular disease model assays to study ciliopathies

Dit ga je doen

Chronic kidney disease (CKD) affects millions globally and remains a major unmet clinical challenge due to the lack of curative strategies. Organoid technology has emerged as a powerful tool to recapitulate organ-specific function in vitro. While progress has been made in other organoid systems, high-throughput and standardized assays in kidney organoids remain underdeveloped. This 4-year PhD project will build upon advances in the field of cellular disease models and high-content screening assays (eg. CellPaint) and extend these strategies to kidney organoids.

As a PhD student, you will aim to develop high-throughput, standardized, and imaging-based platforms for pre-clinical testing in kidney disease, using patient-derived kidney organoids. Such platforms enable prediction of therapeutic outcomes for kidney patients, particularly those with ciliopathies such as nephronophthisis.

Hier ga je werken

You will work as a...