Post Doc - Wolfe Lab

Overview

The Wolfe laboratory will be filling a postdoctoral position to develop therapeutic genome editing reagents for muscular dystrophies and cancer. These projects will focus on:

1) The development of prime editing reagents with high activity and specificity for the precise correction of common pathogenic mutations associated with Limb Girdle Muscular Dystrophy.

2) The development of genome editing reagents for selective killing of cancer cells harboring gene amplifications.

3) The utilization of unbiased genome-wide techniques for assessing off-target events and other genomic alterations potentially associated with genome editing.

4) The translation of the developed genome editing reagents to clinical application through in vivo safety and efficacy studies in relevant mouse models.

Responsibilities

These studies will expose the successful candidate to cutting-edge genome editor engineering approaches an...