Postdoctoral Research Scientist (Epigenetics)

We are seeking a Postdoctoral Research Scientist to join the Houseley group at the Babraham Institute, Cambridge to work on metabolic and genetic dysregulation in ageing.

This BBSRC-funded post addresses the fundamental mechanisms of ageing. Our lab asks why progressive loss of fitness is associated with organismal ageing and whether we can prevent this decline to achieve 'healthy ageing'. We are particularly focused on the ageing genome and epigenome, asking why and how these change in a slow, progressive manner with age, and linking these changes to metabolic dysfunction. We have recently demonstrated that rewiring of acetyl coenzyme A metabolism, which is critical for epigenetic state and DNA repair as well as fatty acid provision, allows yeast cells to maintain full fitness to the end of life (see our bioRxiv manuscript ). Excitingly, this rewiring involves highly conserved pathways and we now have both mouse mutants and human ESC cells ready to test how equivalent metabo...