Research And Development Associate

Job Overview :

We are seeking a highly motivated Research Associate / Scientist to join our Cell and Gene Therapy (CGT) Projects . The role involves hands-on research in immune cell engineering , process development , and functional characterization of engineered cells , while working closely with cross-functional teams including Preclinical, GMP Manufacturing, Quality, and Regulatory Affairs .

This is an exciting opportunity to contribute to cutting-edge immuno-oncology and Build a good Career into CGT Domain & translational research programs.

Suitable Profiles :

• PhD / M.Sc. / M.Tech in Life Sciences, Biotechnology, Biochemistry, Biology, or related disciplines
• 2-5 years of relevant research experience
• Strong foundation in Immunology, Cell Biology, and Molecular Biology

Roles and Responsibilities

• Design, plan, and perform laboratory experiments related to various immune cell engineering and the development of robust manufacturing processes for cell therapy products.
• Manage and execute immune cell culture and differentiation, including primary cell culture, cell line maintenance, and gene modification techniques (e.g., using lentiviral vectors, CRISPR-Cas9 systems, etc.).
• Prior experience in generation of lentiviral vectors, viral infection of primary cells and advanced molecular biology techniques, including gene editing techniques will be preferred.
• Develop and perform a variety of cellular and molecular assays for the functional characterization and phenotyping of the engineered cells, using flow cytometry, ELISA, qPCR, ddPCR, live-cell imaging, metabolic health assessments and co-culture set-ups for cytotoxicity testing.
• Accurately collect, record, analyze, and interpret experimental data. Use statistical analysis (e.g., Design of Experiments/DoE) to determine critical process parameters.
• Be able to troubleshoot experiments, analyse data and interpret scientific presentations.
• Ensure all research activities comply with regulatory requirements.
• Identify, analyze, and resolve technical issues during research and process development, implementing process improvements.
• Present research findings, project progress, and scientific strategy to stakeholders, potentially including external collaborators or conferences.
• Involve in projecting requirements, interacting with vendors, and engaging in the pipeline of procuring new consumables and equipment required for the project.
• Work closely within highly matrixed, cross-functional teams and mentor junior scientists or research associates to advance company's Cell and Gene therapy pipeline.
• Communicate effectively to interface with internal functional departments to support the workflow of various study-related activities.
• Coordinate with Preclinical, GMP manufacturing, Quality control, Quality assurance and supply chain teams and strictly adhere to project timelines by preserving integrity, accuracy, safety and quality.
• Actively engage in non-GMP validation and IND filing studies.
• Prepare and involve in compliance monitoring inspections and regulatory agency interactions.

Understand systems and process pertaining to sterile practices, work ethics, safety, health and environment.

Competencies

• PhD / M.Sc. / M.Tech in Biology, Biotechnology, Biochemistry , or related fields
• Coursework in Cell Biology, Immunology, Molecular Biology
• Strong expertise in T-cell or NK-cell biology , immuno-oncology, and CGT processes
• Hands-on experience in:
• Aseptic processing
• Flow cytometry
• Live-cell imaging
• qPCR / ddPCR
• Viral transduction
• Molecular biology techniques
• Problem Solving
• Excellent analytical and critical thinking skills to resolve complex scientific and process-related challenges
• Strong written and verbal communication skills
• High attention to detail and organizational abilities
• Ability to work efficiently in a fast-paced, collaborative environment
• Strong documentation and record-keeping skills in line with regulatory and quality standards